en روانشناسی Psychology پژوهشي Research <strong>Background and Objective</strong>: Today, cardiovascular diseases are among the leading causes of death in the world. Therefore, the present study aimed to compare the effectiveness of intensive short-term dynamic psychotherapy (ISTDP) and schema therapy (ST) on perceived stress in patients with hypertension at comprehensive health service centers in Sari City, Iran, in 2023.&nbsp;<br> <strong>Materials & Methods</strong>: The current research was a clinical trial study and, in terms of methodology, a quasi-experimental study with a pre-test-post-test design. The research population consisted of all patients suffering from hypertension, and the research sample included 45 individuals selected through purposive sampling. A total of 45 participants were divided into three groups of 15. The first group received intervention type 1 (ST), and the second group received intervention type 2 (ISTDP). As a control group, the third group did not receive any intervention. The perceived stress questionnaire (PSQ) (Cohen et al.,1983), a 9-session ST protocol, and an 11-session ISTDP protocol were used for this study. Data analysis was performed using SPSS software, version 26.<br> <strong>Results</strong>: The results of this study indicated that ISTDP and ST approaches effectively reduced perceived stress in patients with hypertension (P<0.001). The results showed that the Mean&plusmn;SD of the perceived stress score in the ST group after follow-up was 34.06&plusmn;5.96, and that of the ISTDP group after follow-up was 30.17&plusmn;5.88. Also, the Mean&plusmn;SD of the perceived stress score in the control group was 38.46&plusmn;7.63. There was a significant difference between the intervention and control groups after follow-up (P<0.001).<br> <strong>Conclusion</strong>: This study showed that two therapy approaches, ISTDP and ST, are effective in patients with hypertension.&nbsp;<br> &nbsp; Dynamic psychotherapy, Hypertension, Perceived stress, Schema therapy (ST) 187 196 http://cpr.mazums.ac.ir/browse.php?a_code=A-10-218-1&slc_lang=en&sid=1 Mahmoud Reza Hashem Varzi relax_892@yahoo.com 10031947532846002358 0009-0001-5626-0050 No Department of Psychology, Faculty of Humanities, Shahrekord Branch, Islamic Azad University, Shahrekord, Iran. Ahmad Ghazanfari Aghazan5@yahoo.com 10031947532846002359 10031947532846002359 Yes Department of Psychology, Faculty of Humanities, Shahrekord Branch, Islamic Azad University, Shahrekord, Iran.